Special Report Definition of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage as an Outcome Event in Clinical Trials and Observational Studies Proposal of a Multidisciplinary Research Group
نویسندگان
چکیده
Mervyn D.I. Vergouwen, MD, PhD; Marinus Vermeulen, MD, PhD; Jan van Gijn, MD, FRCP, FRCP(Edin); Gabriel J.E. Rinkel, MD; Eelco F. Wijdicks, MD, PhD; J. Paul Muizelaar, MD, PhD; A. David Mendelow, MD, PhD; Seppo Juvela, MD, PhD; Howard Yonas, MD; Karel G. Terbrugge, MD, FRCPC; R. Loch Macdonald, MD, PhD; Michael N. Diringer, MD; Joseph P. Broderick, MD; Jens P. Dreier, MD, PhD; Yvo B.W.E.M. Roos, MD, PhD
منابع مشابه
Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group.
BACKGROUND AND PURPOSE In clinical trials and observational studies there is considerable inconsistency in the use of definitions to describe delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage. A major cause for this inconsistency is the combining of radiographic evidence of vasospasm with clinical features of cerebral ischemia, although multiple factors may contribute to ...
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BACKGROUND AND PURPOSE Methods of performing and reporting randomized clinical trials (RCTs) are available, but weaknesses still occur. For observational studies, methodology is less well described, and weaknesses are even more likely. In recent guidelines for patients with subarachnoid hemorrhage (SAH), 25% of treatment recommendations are based on clinical trials. To interpret the results of ...
متن کاملStudy Design and Outcome Measures in Studies on Aneurysmal Subarachnoid Hemorrhage
Background and Purpose—Methods of performing and reporting randomized clinical trials (RCTs) are available, but weaknesses still occur. For observational studies, methodology is less well described, and weaknesses are even more likely. In recent guidelines for patients with subarachnoid hemorrhage (SAH), 25% of treatment recommendations are based on clinical trials. To interpret the results of ...
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Background: Hypomagnesemia is commonly encountered in patients with a wide variety of diseases including subarachnoid hemorrhage (SAH), cardiovascular emergencies, head trauma, migraine attacks, seizure and preeclampsia. It seems to be associated with a poor clinical outcome. This study considers the prevalence and temporal distribution of hypomagnesemia after aneurysmal SAH and its correlation...
متن کاملMagnesium sulfate for aneurysmal subarachnoid hemorrhage: the end of the road or more trials?
Delayed cerebral ischemia (DCI) is a feared complication and an important cause of poor outcome after aneurysmal subarachnoid hemorrhage (SAH). In the current study, Wong and colleagues performed a systematic review and meta-analysis of randomized controlled trials that investigated the efficacy of magnesium sulfate in patients with aneurysmal SAH. Outcome measures were DCI, cerebral infarction...
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